HCID 86749641, compound → HCID 19705256, compound

HRID 727195Notes

Reaction equation

HRID 727195 reaction equation
C1(=O)CCC([C:7]2[C:12]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:10]=[CH:9][C:8]=2[CH2:17][O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)CC1.[C:27]([NH:29][C:30]([NH2:32])=[NH:31])#[N:28]>C(OCCOCCO)C>[NH2:31][C:30]1[N:29]=[C:27]([NH2:28])[C:8]2[CH2:9][CH:10]([CH:17]([O:18][CH2:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[C:8]3[CH:9]=[CH:10][CH:11]=[C:12]([C:13]([F:16])([F:15])[F:14])[CH:7]=3)[CH2:11][CH2:12][C:7]=2[N:32]=1

Participants

4

Reactant 2

HCID 86749641HCID 86749641, compoundHCID 178418324HCID 178418324, compound

Product 1

HCID 19705256HCID 19705256, compound

Reagents, catalysts & solvents 1

HCID 8146Diethylene Glycol Monoethyl EtherSolvent

Procedure

This compound is prepared in a manner analogous to that of Example 1, using 4.7 grams (0.013 mole) of phenylmethyl [(cyclohexanon-4-yl)(3-trifluoromethylphenyl)]methyl ether and 1.2 grams (0.01 4 mole) of cyanoguanidine in 2-(2-ethoxyethoxy)ethanol, yielding 2,4-diamino-6-[(phenylmethoxy)(3-trifluoromethylphenyl)methyl]-5,6,7,8-tetrahydroquinazoline.

Workup

  1. customThis compound is prepared in a manner analogous to that of Example 1

Sources & evidence

ORD record
ord-11ecf7a63fba423881a0ce4a26428059
Source dataset
uspto-grants-1998_01
Patent number
US05712281

Reaction notes

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