HCID 19705220, compound → HCID 19705205, compound

HRID 727196Notes

Reaction equation

HRID 727196 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[CH2:8][CH:7]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[C:15]=3[O:24]CC3C=CC=CC=3)[CH2:6][CH2:5][C:4]=2[N:3]=1>[Pd].C(O)C>[NH2:1][C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[CH2:8][CH:7]([C:13]3[C:16]([C:20]([F:23])([F:21])[F:22])=[CH:17][CH:18]=[CH:19][C:14]=3[CH2:15][OH:24])[CH2:6][CH2:5][C:4]=2[N:3]=1

Participants

4

Reactant 1

HCID 19705220HCID 19705220, compound

Product 1

HCID 19705205HCID 19705205, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4.3 grams (0.010 mole) of 2,4-diamino-6-[(phenylmethoxy)(3-trifluoromethylphenyl)]methyl-5,6,7,8-tetrahydroquinazoline and a catalytic amount of 5% palladium on charcoal in 30 mL of ethanol is hydrogenated using a Parr hydrogenator. Upon completion of the uptake of the theoretical amount of hydrogen, the reaction mixture is filtered. The filtrate is concentrated under reduced pressure, yielding [(2,4-diamino-5,6,7,8-tetrahydroquinazolin-6-yl)(3-trifluoromethylphenyl)]methanol

Workup

  1. filtrationUpon completion of the uptake of the theoretical amount of hydrogen, the reaction mixture is filtered
  2. concentrationThe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-574424dded684896986d601aeeefbb9e
Source dataset
uspto-grants-1998_01
Patent number
US05712281

Reaction notes

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