HCID 19705231, compound → HCID 19705261, compound

HRID 727199Notes

Reaction equation

HRID 727199 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[O:6][CH:7]1[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]1.[C:19]([NH:21][C:22]([NH2:24])=[NH:23])#[N:20]>C(OCCOCCO)C>[NH2:24][C:22]1[N:21]=[C:19]([NH2:20])[C:11]2[CH2:12][CH:7]([O:6][C:5]3[CH:14]=[CH:15][CH:16]=[C:3]([C:2]([F:18])([F:17])[F:1])[CH:4]=3)[CH2:8][CH2:9][C:10]=2[N:23]=1

Participants

4

Reactant 2

HCID 19705231HCID 19705231, compoundHCID 178418324HCID 178418324, compound

Product 1

HCID 19705261HCID 19705261, compound

Reagents, catalysts & solvents 1

HCID 8146Diethylene Glycol Monoethyl EtherSolvent

Procedure

This compound is prepared in a manner analogous to that of Example 1, using 3.4 grams (0.013 mole) of 4-(3-trifluoromethylphenoxy)cyclohexanone and 1.2 grams (0.014 mole) of cyanoguanidine in 2-(2-ethoxyethoxy)ethanol, yielding 2,4-diamino-6-(3-trifluoromethylphenoxy)-5,6,7,8-tetrahydroquinazoline.

Workup

  1. customThis compound is prepared in a manner analogous to that of Example 1

Sources & evidence

ORD record
ord-ac72de014bbc4220a9fd7a04c59290f3
Source dataset
uspto-grants-1998_01
Patent number
US05712281

Reaction notes

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