Lawesson's reagent → HCID 22105793, compound

HRID 727225Notes

Reaction equation

HRID 727225 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:9][C:10]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)=O)[CH:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:27])=CC=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:9][C:10]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)=[S:27])[CH:3]=1

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 1225859HCID 1225859, compound

Product 1

HCID 22105793HCID 22105793, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2.5 g of product obtained in Example 21 and 5.31 g of Lawesson's reagent are dissolved in 50 ml of toluene, and the solutions maintained at reflux for 4 h. It is filtered and the solvent is evaporated off. The product is purified by chromatography on silica gel, eluting with dichloromethane.

Workup

  1. temperaturethe solutions maintained
  2. temperatureat reflux for 4 h
  3. filtrationIt is filtered
  4. customthe solvent is evaporated off
  5. customThe product is purified by chromatography on silica gel
  6. washeluting with dichloromethane

Sources & evidence

ORD record
ord-9b145c9ab83342a0814630fe8dda1ed6
Source dataset
uspto-grants-1998_01
Patent number
US05712294

Reaction notes

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