HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzaldehyde → HCID 22101856, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzaldehyde | HCID 7726 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | HCID 22101821 | HCID 22101821 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22101856 | HCID 22101856 | — |
Reaction Steps
4-Methyl-5-trimethylsilylthiazole (3 g), 4-chlorobenzaldehyde (4.9 g) and caesium fluoride (2.7 g) in dry tetrahydrofuran (150 ml) were heated under reflux for 30 hours. The mixture was cooled, evaporated to dryness and the residue thus obtained was purified by flash chromatography to afford the title compound. M.p. 133.5°-134.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05712299 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-a4c40aaec3cf45c99ead751a6a54de08 |
| Source note | uspto-grants-1998_01 |