HCID 22101833, compound → HCID 22101855, compound

HRID 727252Notes

Reaction equation

HRID 727252 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH:7]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-])=O)[CH:10]=1)[OH:8]>[Pd].C(O)C>[NH2:15][C:11]1[CH:10]=[C:9]([CH:7]([C:6]2[S:5][CH:4]=[N:3][C:2]=2[CH3:1])[OH:8])[CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 1

HCID 22101833HCID 22101833, compound

Product 1

HCID 22101855HCID 22101855, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1-(4-Methyl-5-thiazolyl)-1-(3-nitrophenyl)methanol (2 g) and 10% palladium on charcoal (200 mg) in ethanol (60 ml) were shaken overnight under an atmosphere of hydrogen. The mixture was filtered and the filtrate was evaporated to dryness. The residue was converted into the hydrochloride salt, recrystallised and then reconverted into the title compound.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated to dryness
  3. customrecrystallised

Sources & evidence

ORD record
ord-3a8aeda5df654d2bbc3c62ace1357293
Source dataset
uspto-grants-1998_01
Patent number
US05712299

Reaction notes

Loading…