Water → 3-(3-(2-Ethoxyethoxy)-1,2,5-thiadiazol-4-yl)pyridine

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	Glycol monoethyl ether	HCID 8076	—
Reactant	Sodium hydride	HCID 24758	—
Reactant	3-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole	HCID 10488164	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	3-(3-(2-Ethoxyethoxy)-1,2,5-thiadiazol-4-yl)pyridine	HCID 19075373	—

Reaction Steps

To a solution of 2-ethoxyethanol (1.08 g, 12 mmol) and sodium hydride (410 mg, 12 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl) pyridine (790 mg, 4 mmol) in dry tetrahydrofuran. The mixture was stirred at room temperature for 2 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05712297
Source dataset	uspto-grants-1998_01
ORD ID	ord-668b2be712fc4efaa4871ed46eb8fecf
Source note	uspto-grants-1998_01