1-Hexanol → 3-[4-(Hexyloxy)-1,2,5-oxadiazol-3-yl]pyridine

Participants

Reaction Conditions

Reaction Steps

To a solution of sodium (100 mg, 4.3 mmol) in 1-hexanol (10 ml) was added 3-(4-chloro-1,2,5-oxadiazol-3-yl)pyridine (180 mg, 1 mmol). The mixture was stirred at 25° C. for 18 h and evaporated. The residue was dissolved in water and extracted with ether. The combined organic phases were dried and evaporated to give the title compound.

Provenance & Evidence