4-Bromoaniline → HCID 19611610, compound

HRID 727458Notes

Reaction equation

HRID 727458 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([CH3:13])=[C:7]([CH3:12])[CH:8]=2)[N:3]=1.[Br:14][C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1>>[Br:14][C:15]1[CH:21]=[CH:20][C:18]([NH:19][C:2]2[CH:11]=[N:10][C:9]3[C:4](=[CH:5][C:6]([CH3:13])=[C:7]([CH3:12])[CH:8]=3)[N:3]=2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 78074-BromoanilineHCID 8253212-chloro-6,7-dimethylquinoxaline

Product 1

HCID 19611610HCID 19611610, compoundYield 37%

Procedure

A preferred method of synthesis of 2-(4-bromophenylamino)-6,7-quinoxaline (Compound 30) is as follows: 200 mg of 2-chloro-6,7-dimethyl quinoxaline (synthesized according to the protocol at Section 5.13, step 2) and 0.8 g of p-bromoaniline were heated at 100° for 3.5 hours. Chromatography gave 25 mg (37% yield) of a light yellow solid, having a melting point of 235° C.

Workup

  1. temperaturewere heated at 100° for 3.5 hours

Sources & evidence

ORD record
ord-6ad68fa7d76f47f0b91fba515d1c6d38
Source dataset
uspto-grants-1998_01
Patent number
US05712395

Reaction notes

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