HCID 10995419, compound → HCID 453631, compound

Participants

Reaction Steps

A solution of 3'-O-(4,4'-dimethoxytrityl)-4'-C-hydroxymethylthymidine (6.32 g, 11.o mmol) in 80% acetic acid in water (50 ml) stood at room temperature fro 4 h. Solvents were removed under reduced pressure and water (200 ml) added. The resulting cloudy mixture was washed with ether (3×80 ml) and water was evaporated. The residue was dissolved in methanol and toluene and the resulting solution was concentrated. This process was repeated twice. 4'-C-hydroxymethylthymidine (2.72 g, 91%) was obtained as a foam.

Provenance & Evidence