Methanol → HCID 22881695, compound

Participants

Reaction Steps

A solution of (S)-tert-butyl N-tert-butyloxycarbonyl-3-(2-methylpropyl)-2-oxo-3-pyrrolidineacetate (193 mg, 0.543 mmol), magnesium methoxide (3.0 mL, 6-10 wt. % in MeOH), and MeOH (2.7 mL) is stirred at room temperature for 16 hours. The solution is poured into water (15 mL) and the mixture acidified with acetic acid. The mixture is extracted several times with CH2Cl2, the combined filtrates dried (MgSO4), filtered, and concentrated to give 124 mg (89%) of the title compound as an oil.

Provenance & Evidence