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Water → Ethyl 3-(2-Methylpropyl)-2,5-dioxo-1-(2-phenylethyl)-3-pyrrolidineacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium periodate | HCID 23667635 | — |
| 反応物 | HCID 53890699 | HCID 53890699 | — |
| 触媒 | Ruthenium dioxide hydrate | HCID 16211523 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | Ethyl 3-(2-Methylpropyl)-2,5-dioxo-1-(2-phenylethyl)-3-pyrrolidineacetate | HCID 53853383 | 65% |
反応手順
Ruthenium(IV) oxide hydrate (27 mg, 0.20 mmol) is added to a mixture of ethyl 3-(2-methylpropyl)-2-oxo-1-(2-phenylethyl)-3-pyrrolidineacetate (prepared similarly to that described in EXAMPLE 1, steps 1-3; 900 mg, 2.71 mmol), sodium periodate (2.71 g, 12.7 mmol), water (27 mL), and CCl4 (27 mL) at room temperature. After stirring overnight at room temperature, aqueous workup (CH2Cl2, MgSO4) and purification by column chromatography (20% EtOAc/hexane) gives 611 mg of the title compound (65%) as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05712300 |
| 出典データセット | uspto-grants-1998_01 |
| ORD ID | ord-c97d9a9927dd40a3b39ffa22aedadc1b |
| 出典メモ | uspto-grants-1998_01 |