Trifluoroacetic acid → HCID 19705446, compound

Participants

Reaction Conditions

Reaction Steps

A cold (0° C.) solution of tert-butyl α-[[[(4-methoxyphenyl)sulfonyl]amino]methyl]-3-(2-methylpropyl)-2-oxo-1-(2-phenylethyl)-3-pyrrolidineacetate (374 mg, 0.669 mmol) in CH2 Cl2 (2 mL) is treated with TFA (2 mL). The solution is maintained at 0° C. for 40 min and then allowed to warm to room temperature under N2. After 1.5 hours, the solution is diluted with CH2Cl2 and stripped (5×). The residual foam is diluted with H2O (5 mL) and extracted into CH2Cl2 (3×20 mL). The extracts are combined, dried over anhydrous MgSO4, filtered, and concentrated under reduced pressure to provide 301 mg (90%) of the title compound as a white, amorphous solid:

Provenance & Evidence