HCID 19705517, compound → HCID 19705568, compound

Participants

Reaction Steps

A solution of α-[2-[(3,4-difluorobenzoyl)amino]ethyl]-N-benzyloxy-3-(3-hydroxypropyl)-2-oxo-1-(2-phenylethyl)-3-pyrrolidineacetamide (215 mg, 0.368 mmol) is dissolved in EtOH (5 mL) and purged with N2. Pearlman's catalyst (22 mg) is added and the atmosphere was replaced with H2 . After 7 hours, the mixture is filtered through celite, washing the residual solids with MeOH, EtOH, and CH2Cl2. The filtrate is concentrated to give 171 mg of a slightly brown foam. The material is crystallized from hot EtOAc (diluting with hexane). The product is isolated and dried in the vacuum oven (45° C.) overnight to provide 117 mg (63%) of the title compound as a cream-colored, powdery solid (mp 118° C., dec.):

Provenance & Evidence