Trifluoroacetic acid → HCID 19705437, compound

Participants

Reaction Conditions

Reaction Steps

A cold (0° C.) solution of tert-butyl α-[2-[(3,4-difluorebenzoyl)amino]ethyl]-2-oxo-1-(2-phenylethyl)-3-(propen-2-yl)-3-pyrrolidineacetate (EXAMPLE 94, step 4; 505 mg, 0.959 mmol) in CH2Cl2 (2 mL) is treated with TFA (2 mL) and maintained at 0° C. for 30 min. The ice bath is removed, and after 1 h, the solution was diluted with CH2Cl2 and concentrated (3×). The residual oil is diluted with H2O (10 mL) and extracted into CH2Cl2 (3×25 mL). The extracts are combined, dried over anhydrous MgSO4, filtered, and concentrated under reduced pressure to provide 430 mg (95%) of the title compound as a slightly yellow, amorphous solid:

Provenance & Evidence