HCID 19705529, compound → HCID 19705509, compound

Participants

Reaction Steps

A solution of α-[2-[(3,4-difluorobenzoyl)amino]ethyl]-N-benzyloxy-3-(2-hydroxyethyl)-2-oxo-1-(2-phenylethyl)-3-pyrrolidineacetamide (117 mg, 0.202 mmol) is dissolved in EtOH (3 mL) and purged with N2. Pearlman's catalyst (10 mg) is added and the atmosphere is replaced with H2. After 6 hours, the mixture is filtered through celite, washing the residual solids with MeOH, EtOH, and CH2Cl2. The filtrate is concentrated and resubjected to the same procedure. The recovered material (99 mg) is purified by silica gel chromatography (8 g SG; 5, 10% MeOH/CHCl3) to give 45 mg of a white, amorphous solid. The solid is triturated with Et2O/hexane, filtered, and dried. This provides 39 mg (40%) of the title compound as a white, powdery solid (mp 135°-137° C.):

Provenance & Evidence