HRID727606

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)C(=O)[C@H](C)[C@H]12

HCID9885302

未命名化合物

结构：CC(=NC(=O)OCc1ccc([N+](=O)[O-])cc1)N1CCN(C(=O)[C@@H]2C[C@H](S)CN2C)CC1

HCID131720425

未命名化合物

PRODUCTS

生成物

结构：CC(=N)N1CCN(C(=O)[C@@H]2C[C@H](SC3=C(C(=O)O)N4C(=O)[C@H]([C@@H](C)O)[C@H]4[C@H]3C)CN2C)CC1

HCID67632398

未命名化合物

收率 8.5%

PROCEDURE

实验过程

Following a procedure similar to that described in Example 1, but using 181 mg of 4-nitrobenzyl (1R, 5R, 6S)-6-[(1R)-1-hydroxyethyl]-1-methyl-2-oxo-1-carbapenam-3-carboxylate and 220 mg of (2S, 4S)-4-mercapto-2-[4-(N-4-nitrobenzyloxycarbonylacetimidoyl)piperazin-1-ylcarbonyl]-1-methylpyrrolidine (prepared as described in Preparation 44), 20 mg of the title compound were obtained, as a powder.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-744d5b633a104381ac5d85289bf86fe6
来源数据集: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05712267
来源说明: uspto-grants-1998_01

反应 SMILES

[OH:1][C@@H:2]([C@H:4]1[C:25](=[O:26])[N:6]2[CH:7]([C:12]([O:14]CC3C=CC([N+]([O-])=O)=CC=3)=[O:13])[C:8](=O)[C@H:9]([CH3:10])[C@H:5]12)[CH3:3].[SH:27][C@@H:28]1[CH2:32][N:31]([CH3:33])[C@H:30]([C:34]([N:36]2[CH2:41][CH2:40][N:39]([C:42](=[N:44]C(OCC3C=CC([N+]([O-])=O)=CC=3)=O)[CH3:43])[CH2:38][CH2:37]2)=[O:35])[CH2:29]1>>[C:42]([N:39]1[CH2:40][CH2:41][N:36]([C:34]([C@@H:30]2[CH2:29][C@H:28]([S:27][C:8]3[C@H:9]([CH3:10])[C@@H:5]4[C@@H:4]([C@H:2]([OH:1])[CH3:3])[C:25](=[O:26])[N:6]4[C:7]=3[C:12]([OH:14])=[O:13])[CH2:32][N:31]2[CH3:33])=[O:35])[CH2:37][CH2:38]1)(=[NH:44])[CH3:43]