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HRID727625

反应详情

EQUATION

反应方程式

HRID 727625 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(CS[C@H]2C[C@@H](C(=O)N3CCN[C@@H](C)C3)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1.Cl
HCID67585387

未命名化合物

结构：CC(=N)NC(=O)OCc1ccc([N+](=O)[O-])cc1
HCID140352007

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(CS[C@H]2C[C@@H](C(=O)N3CCN(C(C)=NC(=O)OCc4ccc([N+](=O)[O-])cc4)[C@@H](C)C3)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1
HCID88299347

未命名化合物

收率 30.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

2.26 g of (2S,4S)-4-(4-methoxybenzylthio)-2-[(3S)-3-methylpiperazin-1-ylcarbonyl]-1-(4-nitrobenzyloxycarbonyl)pyrrolidine hydrochloride [prepared as described in step (i) above] were mixed with 1.14 g of N-(4-nitrobenzyloxycarbonyl)acetamidine and 45 ml of acetonitrile, and the mixture was heated under reflux for 16 hours. At the end of this time, the reaction mixture was worked up and purified by the same procedure as described in Preparation 1(ii), to give 922 mg of the title compound, as a powder.

WORKUP

后处理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 16 hours
  3. custompurified by the same procedure
  4. customas described in Preparation 1(ii)