反应详情

To the liquid mixture of 3-fluoro-4-nitrobenzoic acid 9.71 g and ethanol 35 mL, cone. sulfuric acid 1.6 mL was added, followed by 16 hours' heating under reflux. After distilling the solvent off, water and tert-butyl methyl ether were added to the residue. The organic layer was extracted, washed with water and dried over magnesium sulfate. Distilling the solvent off, 7.40 g of the title compound was obtained.

1. temperature' heating
2. temperatureunder reflux
3. distillationAfter distilling the solvent off, water and tert-butyl methyl ether
4. additionwere added to the residue
5. extractionThe organic layer was extracted
6. washwashed with water
7. dry with materialdried over magnesium sulfate
8. distillationDistilling the solvent off, 7.40 g of the title compound
9. customwas obtained