HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylenediamine → (2S,4S)-4-Mercapto-2-(N-[2-(N-4-nitrobenzyloxycarbonylacetimidoyl)aminoethyl]carbamoyl)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylenediamine | HCID 3301 | — |
| Reactant | (2S,4S)-4-(4-methoxybenzyl)thio-1-(4-nitrobenzyloxycarbonyl)-L-proline | HCID 15297071 | — |
| Reactant | HCID 140352007 | HCID 140352007 | — |
| Product | (2S,4S)-4-Mercapto-2-(N-[2-(N-4-nitrobenzyloxycarbonylacetimidoyl)aminoethyl]carbamoyl)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine | HCID 178465421 | 27.6% |
Reaction Steps
Following a procedure similar to that described in Preparation 17, but using 850 mg of (2S,4S)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)-2-pyrrolidinecarboxylic acid, 450 mg of ethylenediamine and 430 mg of N-(4-nitrobenzyloxycarbonyl)acetamidine, 295 mg of the title compound were obtained as a powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05712267 |
| Source dataset | uspto-grants-1998_01 |
| ORD ID | ord-fdf6f1e4638b4865ad1c7cb5b1d9a6ee |
| Source note | uspto-grants-1998_01 |