HRID727661

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID723833

4-(N-Boc-amino)piperidine

C10H20N2O2

结构：COc1ccc(CS[C@H]2C[C@@H](C(=O)O)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1

HCID15297071

未命名化合物

HCID140352007

未命名化合物

PRODUCTS

生成物

结构：CC(=NC(=O)OCc1ccc([N+](=O)[O-])cc1)NC1CCN(C(=O)[C@@H]2C[C@H](S)CN2C(=O)OCc2ccc([N+](=O)[O-])cc2)CC1

HCID178465420

未命名化合物

收率 97.3%

PROCEDURE

实验过程

Following a procedure similar to that described in Preparation 1, but using 446 mg of (2S,4S)-4-(4-methoxy-benzylthio)-1-(4-nitrobenzyloxycarbonyl)-2-pyrrolidine-carboxylic acid, 220 mg of 4-t-butoxycarbonylamino-piperidine and 119 mg of N-(4-nitrobenzyloxycarbonyl)-acetamidine, 307 mg of the title compound were obtained as a powder.

WORKUP

后处理

customthat described in Preparation 1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2b6bab0f21b54af29a0785d5be197e35
来源数据集: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05712267
来源说明: uspto-grants-1998_01

反应 SMILES

COC1C=CC(C[S:8][C@@H:9]2[CH2:13][N:12]([C:14]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=3)=[O:15])[C@H:11]([C:27]([OH:29])=O)[CH2:10]2)=CC=1.C(OC(N[CH:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1)=O)(C)(C)C.[N+:46]([C:49]1[CH:62]=[CH:61][C:52]([CH2:53][O:54][C:55]([NH:57][C:58](=[NH:60])[CH3:59])=[O:56])=[CH:51][CH:50]=1)([O-:48])=[O:47]>>[SH:8][C@@H:9]1[CH2:13][N:12]([C:14]([O:16][CH2:17][C:18]2[CH:19]=[CH:20][C:21]([N+:24]([O-:26])=[O:25])=[CH:22][CH:23]=2)=[O:15])[C@H:11]([C:27]([N:43]2[CH2:44][CH2:45][CH:40]([NH:60][C:58](=[N:57][C:55]([O:54][CH2:53][C:52]3[CH:51]=[CH:50][C:49]([N+:46]([O-:48])=[O:47])=[CH:62][CH:61]=3)=[O:56])[CH3:59])[CH2:41][CH2:42]2)=[O:29])[CH2:10]1