Trifluoroacetic acid → HCID 22851539, compound

Participants

Reaction Steps

15 ml of trifluoroacetic acid and 0.36 ml of trifluoromethanesulfonic acid were added, whilst ice-cooling, to a solution of 1.47 g of (2S,4S)-4-(4-methoxybenzylthio)-2-[4-(4-nitrobenzyloxycarbonylmethyl) -1-homopiperazinylcarbonyl]-1-(4-nitrobenzyloxycarbonyl)-pyrrolidine [prepared as described in step (i) above] in 2.2 ml of anisole, and the resulting mixture was stirred at room temperature for 1 hour. The solvent was then removed by distillation under reduced pressure, and the resulting residue was repeatedly washed with diethyl ether by decantation and dried in vacuo to give 1.8 g of the title compound, as a powder.

Provenance & Evidence