HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 19824934, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 1-Methyl-4-piperidone | HCID 74049 | — |
| Reactant | 2-(2-Aminophenyl)indole | HCID 735966 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 19824934 | HCID 19824934 | 35.6% |
Reaction Steps
To a solution prepared from 8 g of 2-(2-aminophenyl)indole, 2.5 ml of acetic acid and 100 ml of ethanol was added 5.15 g of 1-methyl-4-piperidone. The mixture was refluxed for 6 hours. Concentration gave a gum which was triturated with dilute NH4OH and the resultant solid was collected. Flash chromatography using 10% CH3OH/CH2Cl2 as an eluent gave 4.15 g of yellow solid, m.p. 228°-230° dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05045539 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-83bd0af77b844f07898944b5d7105241 |
| Source note | uspto-grants-1991_09 |