L-Methionine → HCID 14987013, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5 g of methionine and 25 ml of methane-sulfonic acid is added 5 g of 9-fluoro-2-(4-methoxyphenyl)-5,6-dihydrobenzo[h]cinnolin-3(2H)-one. After the mixture is heated to 55° C. and stirred for 2 days, the reaction mixture is poured into water. The resulting crystals are collected and washed with ethanol to give 4.5 g of 9-fluoro-2-(4-hydroxyphenyl)-5,6-dihydrobenzo[h]cinnolin-3(2H)-one, m.p. 300°-302° C. (decomposition).

Provenance & Evidence