Chloroacetone → HCID 19825008, compound

Participants

Reaction Steps

A mixture of 5 g of 9-fluoro-2-(4-hydroxyphenyl)-5,6-dihydrobenzo[h]cinnolin-3(2H)-one, 4.5 g of chloroacetone, 8.8 g of potassium carbonate and 100 ml of acetone is heated under reflux for 9 hours. After acetone is distilled off, water and isopropyl ether are added to the residue. The resultant crystals are collected and washed with ethanol to give 5 g of crude 9-fluoro-2-[4-(2-oxopropoxy)phenyl]-5,6-dihydrobenzo[h]cinnolin-3(2H)-one, which is subjected to the following reaction without purification.

Provenance & Evidence