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Benzene → 2,2-Dibutyl-4-hydroxy-1-indanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene | HCID 241 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Butyl iodide | HCID 10962 | — |
| 反応物 | 4-{[tert-Butyl(dimethyl)silyl]oxy}-2,3-dihydro-1H-inden-1-one | HCID 15829199 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 生成物 | 2,2-Dibutyl-4-hydroxy-1-indanone | HCID 10659016 | — |
反応手順
A mixture of 4-(tert-butyldimethylsilyl)oxy-1-indanone (524 mg), 1-iodobutane (0.91 ml), and potassium tert-butoxide (896 mg) in dry benzene (15 ml) was refluxed for 2 hours under nitrogen. The reaction mixture was allowed to cool and poured into water. The separated oil was extracted with ethyl acetate. The organic layer was washed with brine, and concentrated in vacuo. The residue was subjected to column-chromatography on silica gel (elution by 10% n-hexane in dichloromethane and then dichloromethane) to yield 2,2-dibutyl-4-hydroxy-1-indanone (150 mg) as crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05045548 |
| 出典データセット | uspto-grants-1991_09 |
| ORD ID | ord-1cffa1623f8c430596a323d79f0bda9f |
| 出典メモ | uspto-grants-1991_09 |