反应详情

75.3 g (0.44 mol) of 2,6-difluorophenylacetic acid are dissolved in 96 ml (156.5 g; 1.32 mol) of thionyl chloride, stirred for 1 hour at 60° and then heated under reflux for 2 hours. The excess thionyl chloride is then distilled off and the residue is fractionated, yielding 79.5 g (95% of the theoretical yield) of 2,6-difluorophenylacetyl chloride.

1. temperatureheated
2. temperatureunder reflux for 2 hours
3. distillationThe excess thionyl chloride is then distilled off
4. customyielding 79.5 g (95% of the