4-[1-(1-Imidazolyl)-butyl]-benzophenone → alpha-[4-[1-(1-Imidazolyl)-butyl]-phenyl]-benzyl alcohol

HRID 727859Notes

Reaction equation

HRID 727859 reaction equation
[N:1]1([CH:6]([C:10]2[CH:23]=[CH:22][C:13]([C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[O:15])=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1.B.[Na]>O1CCOCC1.O>[N:1]1([CH:6]([C:10]2[CH:23]=[CH:22][C:13]([CH:14]([OH:15])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 145143654-[1-(1-Imidazolyl)-butyl]-benzophenoneHCID 178418435HCID 178418435, compound

Product 1

HCID 53827228alpha-[4-[1-(1-Imidazolyl)-butyl]-phenyl]-benzyl alcohol

Reagents, catalysts & solvents 1

HCID 218864351,4-Dioxane--water (1/1)Solvent

Procedure

By reduction of the ketone of example 17 with sodium boron hydride in dioxane/water (90:10); boiling point 250° C./0.03 mbar.

Sources & evidence

ORD record
ord-1a0338175b774e6cb626f2aaf3732d1f
Source dataset
uspto-grants-1991_09
Patent number
US05045558

Reaction notes

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