Water → 4-[1-(1-Imidazolyl)-butyl]-trans-cinnamic acid ethyl ester

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Reaction Steps

0.228 g of 4-[1-(1-imidazolyl)-butyl]-benzaldehyde (example 6) is dissolved in 5 ml of dioxane and mixed with 0.35 g of carbethoxymethylene triphenyl phosphorane and stirred for 48 hours at room temperature. The reaction mixture is poured into 100 ml of water and extracted with ethyl acetate. The organic phases are combined and evaporated to dryness, the residue is distilled on a bulb tube. 0.15 g of the title compound with a boiling point of 200°-220° C./0.03 mbar is obtained.

Provenance & Evidence