Azadirachtin → 108168-76-9

Participants

Reaction Steps

Azadirachtin (30mg, 0.042mmol) and 0.5ml of ethanol was stirred with 20mg of 5% palladiumon alumina at 20° C. under hydrogen (10 atm) for 3 hours. The reaction mixture was then filtered and rotary evaporated in vacuo. The crude product was purified by silica gel preparative HPLC (solvent=2-propanol:n-hexane, 17:83, v/v), followed by ODS preparative HPLC (solvent=methanol:water, 1:1, v/v) to give 2',3',22,23-tetrahydroazadirachtin (18mg).

Provenance & Evidence