Ammonia → HCID 135670757, compound

HRID 728018Notes

Reaction equation

HRID 728018 reaction equation
CS[C:3]1[N:4]=[N:5][C:6]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH2:20][CH2:21][CH3:22])[NH:10][C:9](=[O:23])[C:7]=2[N:8]=1.[NH3:24]>>[NH2:24][C:3]1[N:4]=[N:5][C:6]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH2:20][CH2:21][CH3:22])[NH:10][C:9](=[O:23])[C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 135670760HCID 135670760, compound

Product 1

HCID 135670757HCID 135670757, compound

Procedure

5,6-Dihydro-3-methylthio-5-oxo-7-(2-propoxyphenyl)pyrimido[5,4-e][1,2,4]triazine (0.7 g) was heated for 30 hours with ethanolic ammonia (50 ml) at 100° C. in a pressure vessel. The cooled mixture was filtered to give the crude product (0.21 g) which was recrystallised from ethanol to give the pure title compound, m.p. 322°-325° C.

Workup

  1. filtrationThe cooled mixture was filtered
  2. customto give the crude product (0.21 g) which
  3. customwas recrystallised from ethanol

Sources & evidence

ORD record
ord-12bb146ed80d43dda138d9ac332f2b12
Source dataset
uspto-grants-1991_09
Patent number
US05047404

Reaction notes

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