Ammonia → HCID 135670753, compound

HRID 728021Notes

Reaction equation

HRID 728021 reaction equation
CS[C:3]1[N:4]=[N:5][C:6]2[C:12](=[O:13])[NH:11][C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])=[N:9][C:7]=2[N:8]=1.[NH3:24]>>[NH2:24][C:3]1[N:4]=[N:5][C:6]2[C:12](=[O:13])[NH:11][C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])=[N:9][C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 135670800HCID 135670800, compound

Product 1

HCID 135670753HCID 135670753, compound

Procedure

In a similar manner to that described in Example 10, 3-methylthio-8-oxo-6-(2-propoxyphenyl)-7,8-dihydropyrimido[4,5-e][1,2,4]triazine (1.42 g) was reacted with ethanolic ammonia (70 ml) for 20 hours to give the crude title compound, (0.80 g) which together with another sample (0.17 g), similarly prepared, was recrystallised from ethanol to afford the title compound, 0.54 g, m.p. 255°-256° C.

Workup

  1. customto give the crude title compound, (0.80 g) which together with another sample (0.17 g)
  2. customsimilarly prepared
  3. customwas recrystallised from ethanol

Sources & evidence

ORD record
ord-179a67eae0434631b7dcca3e3bfeb14b
Source dataset
uspto-grants-1991_09
Patent number
US05047404

Reaction notes

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