Sodium Methoxide → HCID 135670758, compound

HRID 728023Notes

Reaction equation

HRID 728023 reaction equation
CS[C:3]1[N:4]=[N:5][C:6]2[C:12](=[O:13])[NH:11][C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])=[N:9][C:7]=2[N:8]=1.[CH3:24][O-:25].[Na+]>>[CH3:24][O:25][C:3]1[N:4]=[N:5][C:6]2[C:12](=[O:13])[NH:11][C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])=[N:9][C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 10942334Sodium MethoxideHCID 135670800HCID 135670800, compound

Product 1

HCID 135670758HCID 135670758, compound

Procedure

In a similar manner to Example 11, 3-methylthio-8-oxo-6-(2-propoxyphenyl)-7,8-dihydropyrimido[4,5-e][1,2,4]triazine (0.5 g) was treated for 3 hours with sodium methoxide (prepared from sodium, 0.17 g, and methanol) to afford the title compound, 0.34 g, m.p. 234°-235° C. (recrystallised from methanol).

Workup

  1. customto afford
  2. customthe title compound, 0.34 g, m.p. 234°-235° C. (recrystallised from methanol)

Sources & evidence

ORD record
ord-0a079f10f86d44e09d39851518db2a16
Source dataset
uspto-grants-1991_09
Patent number
US05047404

Reaction notes

Loading…