HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-Methylthio-8-oxo-6-(2-cyclopropylmethoxyphenyl)-7,8-dihydropyrimido[4,5-e][1,2,4]triazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 5-Chloro-3-(Methylthio)-1,2,4-Triazine-6-Carboxylate | HCID 11557703 | — |
| Reactant | 2-Cyclopropoxybenzamidine hydrochloride | HCID 22462406 | — |
| Product | 3-Methylthio-8-oxo-6-(2-cyclopropylmethoxyphenyl)-7,8-dihydropyrimido[4,5-e][1,2,4]triazine | HCID 135670786 | 59.8% |
Reaction Steps
In a similar manner to Example 18 reaction of 3-methylthio-5-chloro-6-carboethoxy-1,2,4-triazine (prepared from 3-methylthio-5-oxo-6-carboethoxy-4,5-dihydro-1,2,4-triazine, 1.5 g) with 2-cyclopropoxybenzamidine hydrochloride (2.35 g) and triethylamine (1.75 g) afforded a yellow solid (1.31g) which was recrystallised from acetonitrile and then from acetonitrile/ethanol (50%) to afford the title compound, 0.70 g, m.p. 235-236° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05047404 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-f08aef7edbee45f9aa5dfc1830b3c509 |
| Source note | uspto-grants-1991_09 |