Methyl Isocyanate → HCID 19823458, compound

HRID 728079Notes

Reaction equation

HRID 728079 reaction equation
[CH2:1]([N:4]([CH2:17][CH2:18][CH3:19])[CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[C:8]([CH2:15][NH2:16])[CH:9]=[CH:10][CH:11]=2)[CH2:6]1)[CH2:2][CH3:3].[CH3:20][N:21]=[C:22]=[O:23]>C1(C)C=CC=CC=1>[CH2:17]([N:4]([CH2:1][CH2:2][CH3:3])[CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[C:8]([CH2:15][NH:16][C:22]([NH:21][CH3:20])=[O:23])[CH:9]=[CH:10][CH:11]=2)[CH2:6]1)[CH2:18][CH3:19]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 14181206HCID 14181206, compound

Product 1

HCID 19823458HCID 19823458, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1.6 g (6 mmol) of 2-dipropylamino-8-aminomethyl-1,2,3,4-tetrahydronaphthalene were dissolved in 16 ml of toluene under nitrogen. 0.34 g (6 mmol) of methyl isocyanate was added dropwise at a maximum of +25° C. The batch was subsequently stirred for a further 1.5 h at room temperature. The reaction product which crystallized out was then filtered off under suction and dried at +40° C. in vacuo.

Workup

  1. customThe reaction product which crystallized out
  2. filtrationwas then filtered off under suction
  3. customdried at +40° C. in vacuo

Sources & evidence

ORD record
ord-dbe10d6806c64e2ca63c8c9ced5269e2
Source dataset
uspto-grants-1991_09
Patent number
US05047422

Reaction notes

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