化工社化工社 化学情報印刷レポート · 研究参考用
Nilotinib Hydrochloride Anhydrous → Nilotinib
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nilotinib Hydrochloride Anhydrous | HCID 16006490 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Nilotinib | HCID 644241 | — |
反応手順
4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide hydrochloride (14 g) is dissolved in 1,000 g of methanol in a hot water bath. The solution is spray dried in a Buchi Mini spray at about 65° C. to form the amorphous hydrochloride salt of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829015B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-e4e78fc2852f470bbd32a2eea39b6bc6 |
| 出典メモ | uspto-grants-2014_09 |