Acetic Anhydride → HCID 10400088, compound

Participants

Reaction Steps

A solution of 3-methyl-2-[2-(4-aminophenyl)ethyl]pyridine (14.2 g) and acetic anhydride (13.65 g) in ethyl acetate (150 ml) was stirred at ambient temperature for 2 hours. The reaction mixture was washed with saturated sodium bicarbonate solution and brine successively and dried over magnesium sulfate. The solvent was evaporated in vacuo and the residue was recrystallized from a mixture of diethyl ether and ethyl acetate to give 3-methyl-2-[2-(4-acetamidophenyl)ethyl]pyridine (16.3 g).

Provenance & Evidence