Ethyl isocyanate → HCID 15171497, compound

HRID 728124Notes

Reaction equation

HRID 728124 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH:5]=[CH:6][C:7]=1[OH:8].[CH2:17]([N:19]=[C:20]=[O:21])[CH3:18]>C(O)C>[CH2:17]([NH:19][C:20](=[O:21])[NH:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH:5]=[CH:6][C:7]=1[OH:8])[CH3:18]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 15171493HCID 15171493, compound

Product 1

HCID 15171497HCID 15171497, compoundYield 82.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-[2-(3-amino-4-hydroxyphenyl)ethyl]pyridine (3.2 g) and ethyl isocyanate (1.58 g) in ethanol (80 ml) was stirred at 35° to 40° C. for 2 hours. The reaction mixture was evaporated in vacuo and the residue was recrystallized from a mixture of ethyl acetate and diethyl ether to give 2-[2-{3-(3-ethylureido)-4-hydroxyphenyl}ethyl]pyridine (3.5 g).

Workup

  1. customThe reaction mixture was evaporated in vacuo
  2. customthe residue was recrystallized from a mixture of ethyl acetate and diethyl ether

Sources & evidence

ORD record
ord-36e74f781cda493c8c6b44311570c4ad
Source dataset
uspto-grants-1991_09
Patent number
US05047411

Reaction notes

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