Ethyl isocyanate → HCID 15684657, compound

Participants

Reaction Steps

A solution of 2-[2-(4-amino-3-hydroxyphenyl)ethyl]-7-methylimidazo[1,2-a]pyridine (20.0 g) and ethyl isocyanate (7.7 ml) in a mixture of tetrahydrofuran (200 ml) and methanol (200 ml) was stirred for 2.5 hours at ambient temperature. Evaporation of the solvent gave a residue, which was triturated with ethyl acetate to give a precipitate. The precipitate was collected by filtration and dried to give 2-[2-{4-(3-ethylureido)-3-hydroxyphenyl}ethyl]-7-methylimidazo[1,2-a]pyridine (17.86 g).

Provenance & Evidence