Ethyl Acetate → HCID 15684659, compound

Participants

Reaction Steps

The mixture of 2-[2-(4-amino-3-hydroxyphenyl)ethyl]-3,7-dimethylimidazo[1,2-a]pyridine (2.5 g) and methyl isocyanate (0.6 ml) in tetrahydrofuran (25 ml) and methanol (2.5 ml) was stirred for 1 hour at ambient temperature. To the reaction mixture was added ethyl acetate (30 ml) and the precipitate was collected by filtration. The precipitate was washed with ethyl acetate and dried to give 3,7-dimethyl-2-[2-{3-hydroxy-4-(3-methylureido)phenyl}ethyl]imidazo[1,2-a]pyridine (2.92 g).

Provenance & Evidence