Potassium Carbonate → HCID 10083053, compound

Participants

Reaction Steps

A solution of 2-(4-aminobenzyl)pyridine (4.5 g) and ammonium thiocyanate (3.7 g) in acetic acid (50 ml) was stirred at ambient temperature for 1 hour. A solution of bromine (1.3 ml) in acetic acid (5 ml) was dropwise added thereto at 10° to 15° C. under stirring and the resulting mixture was stirred at 10° to 20° C. for 1 hour. A mixture of ethyl acetate and water was added to the reaction mixture and the mixture was adjusted to pH 7.5 with potassium carbonate. An insoluble material was filtered off and the filtrate was separated. The resulting organic layer was washed with brine and dried over magnesium sulfate. The solvent was evaporated and triturated with ethyl acetate. The precipitate was collected by filtration and dried to give 6-[(2-pyridyl)methyl]-2-aminobenzothiazole (0.83 g).

Provenance & Evidence