Potassium Carbonate → HCID 9993129, compound

Participants

Reaction Steps

A mixture of 2-[2-{4-(3-ethylureido)-3-hydroxyphenyl}ethyl]pyridine (3.3 g) and polyphosphate ester (30 g) was stirred at 90° to 100° C. for 1.5 hours. The reaction mixture was dissolved in a mixture of ethyl acetate, tetrahydrofuran and water and the resultant solution was adjusted to pH 8 with potassium carbonate. The separated organic layer was washed with brine and dried over magnesium sulfate. The crude product obtained by concentration was purified by silica gel column chromatography eluting with a solution of chloroform and methanol (39:1 V/V). The eluted fractions containing desired product were evaporated to give 6-[2-(2-pyridyl)ethyl]-2-ethylaminobenzoxazole (0.5 g).

Provenance & Evidence