Hydrochloric Acid → HCID 9997860, compound

Participants

Reaction Steps

To a solution of 6-[2-(5-methyl-2-pyridyl)ethyl]-2-aminobenzothiazole (1.35 g) in acetic acid (15 ml) was dropwise added a solution of bromine (0.8 g) in acetic acid (2 ml) at 20° to 22° C. under stirring and the resultant mixture was stirred at ambient temperature for 5 hours. The reaction mixture was poured into a mixture of water and ethyl acetate and the mixture was acidified to pH 1.0 with 10% hydrochloric acid. The separated aqueous layer was adjusted to pH 8.0 with aqueous 20% potassium carbonate and extracted with a mixture of ethyl acetate and tetrahydrofuran. The extract was washed with brine and dried over magnesium sulfate. The solvent was evaporated in vacuo and residue was recrystallized from a mixture of ethyl acetate and tetrahydrofuran to give 6-[2-(5-methyl-2-pyridyl)ethyl]-2-amino-4-bromobenzothiazole (0.9 g).

Provenance & Evidence