HCID 67836422, compound → HCID 15684647, compound

Participants

Reaction Steps

A solution of 2-[2-(3-benzyloxy-4-nitrophenyl)vinyl]-7-ethoxy-3-methylimidazo[1,2-a]pyridine (3.8 g) in N,N-dimethylformamide (80 ml) was subjected to catalytic reduction over 10% palladium on carbon (1.9 g) under atmospheric pressure of hydrogen gas at 40° to 60° C. for hours. The catalyst was removed by filtration and the filtrate was evaporated in vacuo. The residue was triturated with a mixture of diethyl ether and diisopropyl ether and the precipitate was collected by filtration to give 2-[2-(4-amino-3-hydroxyphenyl)ethyl]-7-ethoxy-3-methylimidazo[1,2-a]pyridine (1.73 g).

Provenance & Evidence