Hydrochloric Acid → HCID 15684649, compound

Participants

Reaction Steps

A mixture of 2-[2-(4-amino-3-hydroxyphenyl)ethyl]-7-methoxycarbonyl-3-methylimidazo[1,2-a]pyridine (2.0 g) in tetrahydrofuran (50 ml) was dropwise added to a mixture of lithium aluminum hydride (0.7 g) in tetrahydrofuran (60 ml) at -20°~-10° C. over 30 minutes and the mixture was stirred at the same temperature for 30 minutes. To the reaction mixture was dropwise added a mixture of water (10 ml) and tetrahydrofuran (20 ml), and the mixture of ethyl acetate, tetrahydrofuran and water was added thereto. The mixture was adjusted to pH 8 with 6N-hydrochloric acid and the insoluble material was removed by filtration. The separated organic layer from filtrate was washed with brine and dried over magnesium sulfate. The solvent was evaporated and the residue was triturated with a mixture of diethyl ether and ethyl acetate to give 2-[2-(4-amino-3-hydroxyphenyl)ethyl]-7-hydroxymethyl-3-methylimidazo[1,2-a]pyridine (1.19 g).

Provenance & Evidence