Cyanogen Bromide → HCID 15684562, compound

Participants

Reaction Steps

A mixture of 2-[2-(4amino-3-hydroxyphenyl)ethyl]-7-ethoxy-3-methylimidazo[1,2-a]pyridine (1.6 g) and cyanogen bromide (0.7 g) in ethanol (24 ml) was stirred for 1.5 hours at ambient temperature. The solvent was evaporated in vacuo. To the residue was added a mixture of tetrahydrofuran, ethyl acetate and water, and the mixture was adjusted to pH 8 with 20% aqueous potassium carbonate solution. The separated organic layer was washed with brine and dried over magnesium sulfate. The solvent was evaporated and the residue was triturated with a solution of diethyl ether and ethyl acetate and precipitate was collected by filtration to give 6-[2-(7-ethoxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]-2-aminobenzoxazole (1.12 g).

Provenance & Evidence