反应详情

1,9-Dimethylphenothiazine (4.2026 g, 18.49 mmol) was dissolved in 130 mL of chloroform and crushed iodine (14.1 g, 55.55 mmol, 3 eq.) dissolved in 520 mL of chloroform was added over 2 hurs. Once newly formed precipitate was filtered off or the solvent removed under vacuum, the resulting iodide salt was stirred with ether or hexane (sometimes overnight) to remove excess iodine then refiltered. After pumping down under vacuum, a brown precipitate was obtained as product (12.6 g).

1. additionwas added over 2 hurs
2. filtrationOnce newly formed precipitate was filtered off
3. customthe solvent removed under vacuum
4. customto remove excess iodine
5. customa brown precipitate was obtained as product (12.6 g)