Pyridine → HCID 15684587, compound

Participants

Reaction Conditions

Reaction Steps

A solution of acetyl chloride (1.94 g) in dichloromethane (6 ml) was added dropwise to a solution of 2-amino-6-[2-(7-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (6.00 g) and pyridine (4.92 ml) in dichloromethane (60 ml) with stirring at 0° C. The mixture was stirred for two hours at the same temperature and further 22 hours at ambient temperature. Saturated aqueous sodium hydrogen carbonate solution (100 ml) was added thereto and that was stirred for 2.5 hours at 0° C. The resulting precipitate was collected by filtration and washed with water. Recrystallization from a mixture of ethanol and diethyl ether gave 2-acetylamino-6-[2-(7-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (4.00 g).

Provenance & Evidence