Hydrochloric Acid → 2-Amino-6-[2-(7-carboxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole

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Reaction Steps

A mixture of 2-amino-6-[2-(7-methoxycarbonyl-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (0.8 g) in methanol (8 ml) and 1N sodium hydroxide (6.8 ml) was stirred for 20 hours at ambient temperature. To the reaction mixture was added a water and the mixture was adjusted to pH 5 with 4N-hydrochloric acid. The isolated precipitate was collected by filtration and dried to give 2-amino-6-[2-(7-carboxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (0.24 g).

Provenance & Evidence