Potassium Carbonate → HCID 15684612, compound

Participants

Reaction Steps

A mixture of 2-amino-6-[2-(7-hydroxymethyl-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (0.5 g) and thionyl chloride (5 ml) was stirred for 40 minutes under ice-cooling. The reaction mixture was poured into ice-water and the mixture was adjusted to pH 8 with 20% aqueous potassium carbonate solution. The aqueous mixture was extracted with a mixture of tetrahydrofuran and ethyl acetate. The extract was washed with brine and dried over magnesium sulfate. The solvent was evaporated and triturated with diethyl ether to give 2-amino-6-[2-(7-chloromethyl-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (0.42 g).

Provenance & Evidence